| Safe People | |
|---|---|
| Lead applicant organisation name | University Hospitals Birmingham |
| Safe Projects | |
|---|---|
| Project title | A study to assess the determinants of aortic stenosis progression and to understand strategies which may delay/halt disease progression. |
| Lay summary | "The project focuses on understanding the factors that contribute to the progression of aortic stenosis (AS), a condition caused by calcium buildup that narrows the heart valve, primarily affecting older adults. Researchers aim to develop a risk stratification tool to identify individuals who rapidly progress from mild to severe AS, enabling targeted interventions and potentially avoiding valve replacement through treatments like lipoprotein (a)-lowering drugs. Using retrospective data from clinical systems, the study will analyse patient demographics, socioeconomic factors, co-morbidities, and biomarkers, alongside echocardiographic parameters like valve area and pressure gradients. The findings will guide the creation of a dataset and inform a research grant application to enhance personalized care and improve outcomes for AS patients." |
| Public benefit statement | "Aortic stenosis (AS) remains the last major cardiovascular disease without effective medical treatment. Up to 75% of patients with less severe or asymptomatic AS either die or require valve replacement within 5 years of diagnosis. This invasive procedure carries risks, and demand for it will soon exceed capacity. Identifying rapid progressors allows targeted risk factor modification to slow disease progression. Testing Lp(a)-lowering drugs may halt progression, potentially eliminating the need for invasive procedures. Benefits to patients: -Targeted management via insights into AS epidemiology and risk factors. -Longer years in better health through optimized risk factor control. -Transitioning focus from treatment to prevention. -Reduced need for high-risk surgical procedures. Benefits to the NHS: -Reduced demand for frequent echocardiograms amid workforce shortages and increasing waiting lists. -Better allocation of resources to support proactive disease management." |
| Latest approval date | 29/01/2025 |
| Safe Data | |
|---|---|
| Dataset(s) name | PATHWAY Research Data Hub: PWY029 dataset |
| Safe Setting | |
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| Access type | Data released via Letter of Authorisation. All researchers have received training in the care, use and protection of personal data, enabling them to comply with their responsibilities under the Data Protection Act. |
| Safe Outputs | |
|---|---|
| Link | Not yet Published |