Safe People
Lead applicant organisation name	University Hospitals Birmingham

Safe Projects
Project title	Perioperative hypotension and its association with outcomes in kidney transplant
Lay summary	A kidney transplant is the best treatment for people with severe kidney failure, helping them live longer and have a better quality of life than dialysis. After a transplant, it is important to keep blood pressure at the right level so that enough blood flows to the new kidney. However, doctors do not yet know what the best blood pressure target is, how best to manage it, or how low blood pressure before surgery affects transplant success. We also do not know which patients are most likely to develop low blood pressure after their transplant. This study aims to answer these questions. The researchers will find out how common low blood pressure is before and after kidney transplant, whether patients with low blood pressure before surgery have successful transplants, and what blood pressure levels in the first week after transplant lead to the best kidney function. They will also look at which blood pressure treatments are used after transplant and who is most at risk of developing low blood pressure. To do this, the team will use information routinely collected during patient care, including blood pressure readings, kidney function, dialysis needs, and scan results. The findings will help doctors better manage blood pressure after transplant, identify patients at higher risk, and make the best use of donated kidneys.
Public benefit statement	There are currently no guidelines available for the management of low blood pressure before or after kidney transplant. This may reflect a paucity of published articles to guide evidence-based decision making. The researchers hope that our project will advance the field by identifying postoperative blood pressure targets associated with improved outcomes, paving the way for more definitive prospective trials. In addition, this work on preoperative hypotension may lead to altered criteria for what is considered an adequate blood pressure prior to listing for transplant. Finally, by identifying novel factors which predict postoperative hypotension, they hope to be able to proactively identify and intervene for these patients before hypotension develops, leading to improved outcomes.
Latest approval date	05/05/2026

Safe Data
Dataset(s) name	PATHWAY Research Data Hub: PWY047 dataset

Safe Setting
Access type	Project approved via Proportionate Review Process. Data released via Letter of Authorisation. All researchers have received training in the care, use and protection of personal data, enabling them to comply with their responsibilities under the Data Protection Act.

Safe Outputs
Link	Not yet Published