Safe People
Lead applicant organisation name	University of Birmingham

Safe Projects
Project title	Role of radiomics for differential diagnosis of adrenal tumours
Lay summary	"GOALS: Adrenal tumours are common and mostly benign. However, distinguishing benign (harmless) from cancerous ones is hard. A large study in Europe is looking at using a special way of analysing X-ray images (called radiomics) to help with this. Before doctors can use this method in hospitals for routine care of patients, they need to make sure it is reliable and works well. Therefore, the method is being tested on patients with adrenal tumours at UHB Endocrine Department, a hospital that looks after many patients with these tumours. REASONING: The accidental discovery of adrenal tumours has skyrocketed in the last three decades due to the ever-increasing use of imaging of the chest and tummy. Most adrenal tumours are harmless and usually have reassuring imaging characteristics; however, more than one in three has appearances like cancerous ones. As a result, many patients with adrenal tumours undergo unnecessary surgery to remove the tumour. A better way to tell adrenal tumours apart is needed. A game-changing tool could be represented by radiomics, a technique that allows obtaining very detailed information from X-rays. Radiomics has been tried for other cancers and works very well, but it has not been tested in adrenal tumours. "
Public benefit statement	"Patients with Adrenal tumours (AT) often require numerous biochemical, radiological, and invasive investigations (including biopsies and surgery) to conclusively rule out malignancy. This journey to diagnosis usually takes months and is a stressful time for the patient. With the validation of the radiomic tool (expected from this project), clinicians will be able to dramatically speed up the clinical decision-making procedure for patients with AT, with clear benefits for both patients and the wider NHS."
Latest approval date	13/03/2025

Safe Data
Dataset(s) name	PATHWAY Research Data Hub: PWY021 dataset

Safe Setting
Access type	Data Licence Agreement between the collaborating organisations using secure and controlled data analysis environments.

Safe Outputs
Link	Not yet Published