The wide use of electronic healthcare records (EHRs) in the NHS, provides the opportunity for digital innovations to improve the efficiency of clinical trials. The DaRe2THINK trial uses a series of novel processes, including nationwide pseudonymized pre-screening of the primary-care EHR, digital enrolment, remote e-consent, and ‘no-visit’ follow-up, to transform the delivery of a randomized control trial.
To ensure the trial provides high-quality and high clinical value results the DaRe2THINK trial used a systematic approach to define patient information and outcome events. This includes transparency on all medical code lists and phenotypes used in the trial across a variety of national data sources.
Link for more information –https://doi.org/10.1093/ehjdh/ztac046