Using routinely collected healthcare data to improve the delivery of clinical trials

The wide use of electronic healthcare records (EHRs) in the NHS, provides the opportunity for digital innovations to improve the efficiency of clinical trials. The DaRe2THINK trial uses a series of novel processes, including nationwide pseudonymized pre-screening of the primary-care EHR, digital enrolment, remote e-consent, and ‘no-visit’ follow-up, to transform the delivery of a randomized control trial.

To ensure the trial provides high-quality and high clinical value results the DaRe2THINK trial used a systematic approach to define patient information and outcome events. This includes transparency on all medical code lists and phenotypes used in the trial across a variety of national data sources.

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Accessing Health Data